Tetrahydrocannabinol (THC) | Noun
- An intoxicating and psychoactive cannabinoid found in cannabis. THC is the most well-known cannabinoid in the plant and is capable of inducing a variety of sensory and psychological effects, including mild reverie, euphoria, increased sensory awareness, and some therapeutic benefits. Historically, cannabis has long been cultivated for its euphoric and therapeutic effects, which are largely attributed to THC.
Science/Animal: THC reduces inflammatory response and organ damage after infection
Mice, which were treated with a toxin causing inflammation, received THC to investigate its effect on inflammation and organ injury. Administration of THC “dramatically” increased the concentration of the anti-inflammatory cytokine interleukin-10, while reducing the concentrations of pro-inflammatory interleukin-6 and CCL-2, which attenuated inflammation and organ injury. Authors concluded that their “results indicate that Δ9-THC potently induces IL-10, while reducing proinflammatory cytokines, chemokines, and related organ injury in endotoxemic mice via the activation of CB1R.”
Department of Anesthesia and Perioperative Care, University of California, San Francisco School of Medicine, USA.
Joffre J, et al. J Immunol. 2020 May 8. [in press]