Tetrahydrocannabivarin (THCV) | Noun
- THCV, Delta-9-tetrahydrocannabivarin (d-9-THCV), is one of the cannabinoid compounds found in the cannabis plant. THCV is a non-intoxicating cannabinoid molecule that interacts with both the CB1 and CB2 cannabinoid receptors, among other targets in the body. This compound is potentially useful in the treatment of epilepsy and obesity [Pertwee, 2008; Izzo et al. 2009].
- “THCV is a naturally occurring analog of THC. Unlike THC, which is psychoactive and an agonist at the CB1 and CB2 receptors, THCV is a non-psychoactive” – Journal of Cannabis Research
- National Library of Medicine, Compound Summary: https://pubchem.ncbi.nlm.nih.gov/compound/Tetrahydrocannabivarin
- Science/Animal: THCV may be helpful in L-DOPA-induced dyskinesia in Parkinson’s disease
In a mouse model for L-DOPA-induced dyskinesia in Parkinson’s disease the natural cannabinoid THCV reduced symptoms. Authors wrote that their data “support the anti-dyskinetic potential of Δ9-THCV, both to delay the occurrence and to attenuate the magnitude of dyskinetic signs.” Instituto Cajal-CSIC, Madrid, Spain. Espadas I, et al. Neurobiol Dis. 2020;141:104892.
- Δ9-Tetrahydrocannabivarin (THCV): a commentary on potential therapeutic benefit for the management of obesity and diabetes – Journal of Cannabis Research